Preimplantation Genetic Screening (PGS) in Delhi, India

Preimplantation genetic screening or PGS in Delhi, India is defined as “a practice of evaluating embryos for chromosomal aneuploidy, presence of a few or too many chromosomes, in chromosomally normal parents“. A normal human body has 23 pairs of chromosomes in each cell of which one pair is a sex linked chromosome; XX in female and XY in males. The chromosomal defects occur randomly even in normal patients during embryo formation or initial cell division of embryos.

PGS in India is a new technique of assisted reproduction; where the cells are screened to check the number of chromosomes or presence of any abnormal chromosome. Any couple undergoing In vitro fertilization (IVF) or Intracytoplasmic Sperm Injection (ICSI) can opt to get their embryos analysed through PGS .The embryos with right chromosome number are selàfor uterine transfer.

Indications of PGS

The indications of using PGS in Delhi, India in the recent past has been constantly expanding. Some of indications of PGS includes:

• Increasing age: Increased age of the mother, father or both can increase the chances of chromosomal defects in the child.
• Male fertility factors : failure of adequate sperm production or decreased sperm quality or any type of gonadal failure is associated with production of chromosomally abnormal embryos.
• Recurrent pregnancy loss : Almost 50% of the pregnancy losses are due to chromosomal anomalies. PGS has shown promising results in decreasing the rate of miscarriages.
• A previous IVF failure: couples with one or more IVF failures can choose to select embryos without genetic anomalies through PGS.
• Unexplained infertility: Couples with no specific cause of their infertility also can opt for PGS to eliminate abnormal embryos during IVF/ICSI.
• Having an affected progeny: Couples having a child with developmental defects can get PGS done to determine the risk of having a subsequent child with defects.

How is the procedure performed?

Similar to PGD, PGS is performed along with IVF or ICSI. The embryos obtained through IVF/ICSI are developed to 6-8 celled stages. One or two cells are extracted and tested through Fluorescent karyotyping or FISH.

FISH or fluorescent in-situ hybridization is a technique where fluorescent markers are used to identify the mutated segment of DNA or chromosomes. Also known as karyotyping; the entire 23 pairs of chromosomes can be observed through fluorescent markers for any chromosomal defects.

OMYA is embellished with exclusive embryology labs with advanced genetic techniques and procedures that can help you seek the best embryos without chromosomal abnormalities.