If you are considering IVF treatment, you have made remarkable progress in your fertility journey. IVF, or in-vitro fertilization, is an assisted reproductive technique that helps couples realize their dream of having a baby.
This procedure involves giving various injections to the woman to help the body get ready hormonally to nurture and carry a baby. A daunting question often asked is, “how many injections for IVF treatment?”
One mature egg will be produced per cycle as part of a woman’s regular menstrual cycle. To increase the likelihood of successful IVF, fertility specialists aim to collect the most eggs in a single round. The IVF injections schedule is an integral part of the treatment.
Before the IVF procedure begins, fertility doctors will decide the duration, dose, and hormone requirements based on blood tests and ultrasonography and determine the dosage and schedule of IVF hormone injections.
Read on to find out more about the procedure, get answers to questions such as how many injections for IVF treatment, and more. Our experts at Omya Fertility will devise a treatment plan for you, keeping in mind the rare side effects of IVF injections, and inform you about the same.
Table Of Content
1. What’s the IVF procedure?
During IVF , mature eggs are collected from ovaries and fertilized by sperm in a IVF lab.
The changes in sex hormones that occur during pregnancy and childbirth are the fundamental inspiration for the design of the IVF method. The IVF procedure requires a set IVF injections schedule and constant monitoring at every stage, which is vital.
The following steps comprise the IVF process:
Step 1: Prerequisites for starting an IVF cycle
- Blood panel test
- Screening for infectious diseases
- Evaluating the uterine lining
Step 2: Suppression of Ovulation and Developing Egg Follicles
Depending on the protocol decided by your doctor on Day 1 of your period, your fertility specialist will prescribe medication to moderate the menstrual cycle and time it with your fertility treatment. On Day 21, you will start taking medication that stimulates the ovaries and prevents ovulation. We refer to this process as ovarian suppression. As a result, during the monthly cycle, the ovaries create numerous mature follicles as opposed to only one.
Your doctor will do a check to ensure that ovulation has been repressed. The woman subsequently begins using drugs for ovarian stimulation which start on day 2 of your period and are given continously for 9-10 days injections are generally recombinant FSH which are given by a tiny needle in subcutaneous fat of stomach. Your egg size is monitored every few days along with blood test to see your response to stimulation and your injections dose may be altered.
Step 3: Preparation for the egg retrieval
An hCG injection will be given precisely 36 hours before the egg retrieval. This medicine promotes the follicles’ release of eggs. The success rate of the IVF cycle is heavily reliant on this procedure, which is known as the trigger shot. Because the eggs will release 38 hours after the trigger shot, time is crucial for this shot. It is therefore essential to gather them before they emerge from the ovaries.
Step 4: Egg retrieval
The actual egg retrieval process is a quick, minimally invasive surgical procedure and will be arranged before the woman receives the trigger shot to guarantee appropriate synchronisation because timing is crucial for this treatment. The egg retrieval and sperm retrieval are typically done on the same day if the male partner is providing the sperm.
After being retrieved, the eggs are taken to a facility where embryologists will grade and test them. The embryologist will determine the precise quantity of healthy, viable eggs they will be working with.
Step 5: Fertilisation
In most situations, egg fertilisation is accomplished by placing the eggs in a petri dish containing the sperm. Fertilization can also be accomplished by the ICSI (Intracytoplasmic Sperm Injection) procedure. In this technique, the sperm sample is used to isolate the most viable sperm and used .
To boost the odds of conception, a single viable sperm is inserted into the egg. Because only one healthy sperm is required for fertilisation, the ICSI approach is extremely beneficial, especially when there are male factors of infertility.
Step 5: Fertilization with IVF
Soon after being recovered or thawed, eggs are fertilised in a special laboratory facility
Step 6: Embryo culture and transfer
After embryos are created, they are cultivated in an IVF facility for 3 to 5 days. The following is the IVF embryo formation timeline:
The embryos are cultured in a medium that is similar to the fluid in the fallopian tubes. The embryos are then placed in another culture medium that simulates the environment surrounding the uterus.
The embryos are then cultured for a few days by the IVF specialist until they reach the blastocyst stage.
Transfer of blastocyst-stage embryos: Although embryos on day 3 may have begun to divide, they only have 6 to 8 cells. Embryos, on the other hand, have approximately 80 to 120 cells by day 5 to 6. Consequently, transferring blastocysts at this time has numerous advantages versus transplanting embryos at the day 2 to 3 stage. The main advantage is they are appropriate for pre-implantation genetic tests (PGT-M/PGT-A) and contributes to the IVF cycle’s success percentage.
Step 7: Preparing the Uterus Lining
Meanwhile, the day after the egg retrieval, the woman begins progesterone injections to nourish the uterine lining and prepares it for the introduction of embryos into the body. This supplement is for 14 to 21 days following the embryo transfer.
Step 8: Transfer of Embryo(s)
The embryo transfer occurs 3 to 5 days following the embryo transfer. The embryo transfer process is similar to intrauterine insemination (IUI). It takes about 15 to 20 minutes and does not require anaesthesia.
During this procedure, the doctor will insert a small, flexible catheter through the cervix into the uterus. The embryo(s) are implanted after being transported directly into the uterus. After that, she should rest for at least 30 minutes before being allowed to go home.
Step 9: Obtaining a Pregnancy Test
A pregnancy test is performed 12 to 14 days following the embryo transfer. A blood test is commonly used to confirm a positive pregnancy since it is more accurate.
2. What exactly are the IVF injections for pregnancy given during ovarian stimulation?
In the first step of IVF, shots are typically given. IVF patients typically receive naturally occurring hormones at a slightly greater dosage (supraphysiological level). These hormones are administered daily for eight to twelve days, long enough to develop eight to twelve healthy (18 to 22 mm) follicles.
Our doctors will discuss the uncommon side effects of IVF injections.
The following are the IVF injections for pregnancy list employed in an IVF procedure used to stimulate the ovaries:
A single follicle’s maturation and the release of a mature egg into the fallopian tube for fertilisation are both aided by gonadotropins, hormones that help with menstruation cycles normally. Drugs that mimic the gonadotropin cycle serve the same purpose.
FSH hormones are crucial in the list of IVF injections for pregnancy and stimulate the growth of numerous follicles at once, which causes the ovaries to produce several mature eggs.
LH hormones enhance the ability of FSH to release mature eggs. Your IVF injections schedule ensures that your body receives all the help it needs during this phase.
This drug is injected 32 to 36 hours before egg retrieval as part of IVF injections for pregnancy. A single subcutaneous injection of hCG triggers the last stage of egg maturation.
How many injections for IVF treatment is the most frequently asked question by couples and causes them a lot of anxiety.
The uterine lining must be prepared for an IVF pregnancy. Hence, these drugs are required during the IVF treatment cycle. These drugs are taken after egg retrieval, which triggers the release of estrogen and progesterone.
Estrogen encourages the endometrium’s expansion and thickness, which is necessary to establish the uterine environment for conception. When frozen or donated embryos are transferred, oestrogen drugs are typically administered.
Progesterone increases the endometrium’s receptivity, making it easier for embryos to implant. After the natural ovulation process, the corpus luteum cells of the ovary generate this hormone.
3. IVF injections—are they painful?
IVF injections for pregnancy are the most integral part of ovarian stimulation. Typically, the arms, thighs, or abdomen are where the injections are given. Again, this is based on the sort of injection used. The injections are generally painless and regarded as safe. Self-administered special fine-needled devices with little to no pain are available.
4. What are the side effects of IVF injections?
The side effects include:
- Blisters and swelling at the injection site
- Ovarian hyperstimulation
- Multiple births
- Ectopic pregnancies
- General irritability
- Breast tenderness
- hot flashes
- blurred vision
5. What are the types of IVF transfer?
#1. “Fresh” transfer
For patients who are seeking to transfer their eggs immediately after retrieval, the embryo can be transferred at 2 different stages of its lifecycle:
They can be transferred on approximately day 2 or 3 after fertilization when they are in their cleavage stage.
They can be transferred on days 5 after fertilization when they are in their blastocyst stage.
The best appearing embryos are deposited into the uterine cavity using a catheter. Patients may experience cramping, bloating, and spotting following this procedure.
#2. “Frozen” transfer
In some scenarios for egg freezing, such as planning for the future, the embryos are not transferred immediately. Under such conditions, embryos are frozen through a process called vitrification.
6. What Happens After IVF Transfer?
After the transfer (0-1 day post retrieval), progesterone supplements provide hormonal support for the successful attachment of the embryo to the uterine lining.
And within 12 days to two weeks, a blood sample is taken to determine if the transfer resulted in a successful pregnancy. This test measures the hCG (human chorionic gonadotropin) levels, often referred to as the “pregnancy hormone,” indicating cells are forming in the placenta to nourish the fertilized egg.
Each IVF injection could cause mild discomfort not pain, which could cause you to panic. Injections used in IVF, however, are not unpleasant. A small dermal piercing is required for these self-administered subcutaneous injections, which are also available. Still worried about How Many Injections for IVF Treatment? Call Now. Omya Fertility is your destination for the best IVF centre in Delhi.
Connect with Dr. Seema Bajaj at Omya fertility- the best infertility doctor in Delhi—to learn more about the schedule, dosage requirements for you , and how the IVF cycle should be carried out.