Intracytoplasmic Sperm Injection (ICSI) technology ideally focuses on injecting the sperm directly into the ovum. ICSI treatment is primarily considered in couples who have low sperm count, less motile sperms, and/or morphologically abnormal sperms that fail to fertilize the egg. This amazing technology gives you options to select sperm without characteristic defects.
In 1992, ICSI came into clinical practice to address male infertility factors and fertilization failure issues. Today, ICSI has been adopted widely and has an added feather in its cap with more progressive technologies like IMSI and PICSI where sperm can be chosen based on morphological and sperm DNA characteristics.
- IMSI Procedure : IMSI is otherwise known as Intracytoplasmic morphologically selected sperm injections. This technology allows the selection of sperms based on their morphological features. This is a relatively new technique where the sperms are magnified by almost 6,600 times to select sperms without any morphological defects. IMSI selection of sperms involves a laborious search of sperms that can take several hours. However, IMSI-selected sperms can be injected into the egg through the ICSI procedure.
- PICSI procedure : While ICSI and IMSI concentrate on the selection of sperms with motility, proper shape, and size. PICSI involves the selection of sperms based on DNA characteristics. Sperm DNA integrity, sperm maturity are essential characteristics to be counted while selecting a more viable sperm. PICSI or Physiological Intracytoplasmic Sperm Injection or physiological ICSI.
PICSI applies the ability of the sperm to get attached to the egg during the natural fertilization process. During the natural fertilization procedure in the fallopian tubes, the outer eggshell has a special hyaluronan bipolymer that gets in contact with the mature sperm to accomplish fertilization. PICSI uses this biopolymer added to the bottom of the plate where the sperms are allowed to bond to the hyaluronan. The hyaluronan binding sperms are morphologically selected and injected into the egg via ICSI. Researchers have shown that PICSI can help demarcate sperm with less DNA damage and fewer chromosomal anomalies.
Effective IVF is also determined by sperm quality. ICSI opens brackets for sperm selection based on various sperm quality parameters. ICSI and advanced ICSI technologies can reduce the likelihood of preterm pregnancy loss and increase the chances of implantation. OMYA fertility center offers the entire suite of andrology treatments and ICSI procedures that can carry out healthy fertilization leading to a fruitful pregnancy.